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Mr Bennett added: "He's going to need a lot of help and our strength for him. Read about our approach to external linking. MND and FTD are devastating diseases which currently have no cure. Send your story ideas to yorkslincs.news@bbc.co.uk. Instead of using conventional drugs, which are inefficient in disrupting the stickiness of the SRSF1 protein, or invasive therapies to edit or modulate the activity of defective genes, the new study found that a small peptide incorporating a cell-penetrating module can stick to SRSF1 and effectively block the transportation of the rogue repeat RNA. "The police are providing support to the family while the investigation continues and we cannot comment further at this time. They said that they were called following reports of "concern for a woman" who was sadly pronounced dead at the scene. It is hoped the innovative research, conducted in collaboration with multiple labs in SITraN and with the groups of Dr Alexander Whitworth (University of Cambridge), Dr Cyril Dominguez (University of Leicester), Professor Frdric Allain (ETH Zurich) and funded by the MND Association and the UKRI BBSRC and MRC councils will transform the future of clinical trials for the most common forms of MND and FTD within the next few years. Emergency services were called to the OYO Sheffield Metropolitan Hotel on Wednesday afternoon, South Yorkshire Police said it was not treating the death as suspicious. The family of two children, who were found dead along with their mother and another child at a house in Derbyshire, have paid tribute to them. "Our thoughts are with all those affected by this sad news.". There is no cure for FTD, and no treatments available to slow or stop the progression of the disease. It is understood a police officer was seriously injured while pursuing a fleeing suspect. FTD occurs when nerve cells in the frontal and temporal lobes of the brain are lost, causing the lobes to shrink. Treatments are very limited and there is no cure. Media contact: For more information please contact: Amy Huxtable, Media and PR Officer, University of Sheffield, 07568116781, a.l.huxtable@sheffield.ac.uk Journal Science Translational Medicine "We don't know the details of the incident but it is imperative that families who come from Afghanistan are given all the support they need and housed in appropriate accommodation. Emergency services were called to the OYO Metropolitan Hotel in Blonk Street, Sheffield, at about 14:30 BST on Wednesday. News. "And it is a day that we'll all remember because this doesn't happen in Killamarsh. 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The third child has been named as Connie Gent, 11, from Sheffield. The man said the eight to 10 Afghan families staying at the hotel were being moved to another hotel on Thursday afternoon. A man was found unconscious in Pond Street, Sheffield, in the early hours of Saturday November 6. Another Afghan resident said he was in his room when he heard the boy fall. The woman was sadly pronounced dead at the scene. The council will be renewing its nine Public Space Protection Orders until 2026. John Paul and Lacey's father Jason Bennett said "life will never be the same again", Lacey and John Paul's mother Terri Harris was found dead at the house, Local residents have been lighting candles at St Giles Church, Specially-trained officers are liaising with the families of the deceased, Flowers have been left near the police cordon on Chandos Crescent, People started gathering for a candlelit vigil in the local park earlier on Monday night, Mourners also left flowers and teddies alongside the candles. Dr Brian Dickie, Director of Research at the MND Association, said: These findings from a world leading research team in Sheffield demonstrate the importance of funding fundamental discovery science. But it has. "I met the father this morning and as you can imagine he's in a really bad way and all I could do is comfort him and pray with him, and he appreciated that.". 20 February 20 Feb. "I've only spoken to him on the phone and it breaks my heart to hear him like that.". To get the latest email updates from South Yorkshire Live, click here . Chief Constable Rachel Swann described the deaths as a "shocking event". "It's really important we build as full a picture as possible of events leading up to the discovery of the woman's body this morning, so we want to hear from anyone living locally who may have seen, heard or noticed anything suspicious over the last few weeks.". The BBC is not responsible for the content of external sites. Write your will online; Lasting power of attorney; Probate in Sheffield Support your loved one - create a free obituary. Send your story ideas to yorkslincs.news@bbc.co.uk. A man has tragically died after his car came off the road in a horror crash in Sheffield's city centre. Hundreds of people from the Killamarsh community gathered at Baker Park near Chandos Crescent on Monday night for a vigil. Derbyshire Police said they were called to the house at 07:26 BST on Sunday after concerns were raised about the safety of a man. Copy Citation. The Sheffield team previously discovered the abnormal transportation of the rogue RNAs copied from the C9ORF72 gene - known to be the most frequent cause of MND and FTD - is caused by excessive stickiness of a cell transporter named SRSF1. It also left three other people needing When I came here [outside] I saw the ambulance and police here. Read about our approach to external linking. Local obituaries for Sheffield, Alabama 38 Results Saturday, February 18, 2023 Add Photos Add a Memory Akevia Emil Smith Akevia Smith's passing on "They are so upset, they are so unhappy," he said. Mrs Bennett said Lacey was a West Ham fan and John Paul liked TikTok and computers. "As a council we are in close contact with the police and will provide any support that we can to the family - my heart goes out to them.". WebLive Sheffield news, including the latest headlines on travel, crime, local politics, M1 updates, events and much more on South Yorkshire's largest settlement. "My thoughts just go out to the whole family," she said. The BBC is not responsible for the content of external sites. South Yorkshire Police said the body was discovered at an address in 2023 BBC. This research was pump-primed by a MND Association biomedical grant and further supported by UKRI through BBSRC and MRC New Investigator research grants. 1937 - 2021, aged 84. WebLive-event. 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The BBC is not responsible for the content of external sites. In a message posted on Facebook earlier, he said "life will never be the same". The children's grandparents, Debbie and Trevor Bennett, also arrived at the scene to leave flowers. 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Researchers from the University of Sheffields Institute of Translational Neuroscience have discovered how to prevent the death of nerve cells and protect nerves from neurodegeneration in the most common forms of MND and frontotemporal dementia, The researchers used a peptide, a small assembly of amino acids or protein bricks, with a cell-penetrating module to stop mutant repeated RNA molecules being transported from the cell's nucleus to the cytoplasm where they are used to produce toxic repeat proteins which lead to the death of nerve cells, Findings of the study suggest the peptide could be given orally in a non-invasive manner - for example through a nasal spray which could be developed to enter the brain, The ground-breaking concept of using peptides to block the nucleus-to-cytoplasm transport of the damaging repeat expanded RNA could transform how some neurodegenerative conditions, which currently have no cure, are treated. A woman has been found dead at a flat in Sheffield after officers forced entry to the property. MND is a debilitating condition that destroys the cells that control movement, leaving sufferers unable to move, walk, talk and eventually breathe. This is a promising alternative to conventional small molecule drugs which are often limited by poor penetration of the blood-brain barrier.. 4d. Sheffield & South Yorkshire. Or by navigating to the user icon in the top right. 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