People with TMAU are born with a defective version of the gene that codes for FMO3 and the resulting faulty FMO3 enzyme is unable to completely break down trimethylamine. GARD is not currently aware of organizations specific to this condition. More than 100 cases have been reported in medical literature, but some clinicians believe its underdiagnosed. Because of the biochemical nature of the excessive production of TMA, TMAU is linked to the intake of choline-rich foods, including eggs; broccoli; certain legumes such as soy, kidney beans; wheat germ; saltwater fish; and organ meats, including liver. TMAU symptoms often get worse during puberty, making children vulnerable to being bullied, shunned or ridiculed. 11/2018 . Testing can be done by giving choline by mouth followed by urine collection a certain number of times over a 24 hour period. We all have two copies of the gene that causes trimethylaminuria, FMO3. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Kabuki syndrome is a genetic syndrome that may be random or autosomal dominant. TMAU is diagnosed using a biochemical laboratory test that measures the amount of trimethylamine in a patients urine after they drink juice containing added choline. Trimethylamine N-oxide is present in seafood, including: Additionally, its important to avoid milk from wheat-fed cows. To find the right clinical study we recommend you: ResearchMatch helps connect people interested in research studieswith researchers from top medical centers across the United States. There is no cure. You should always contact your doctor or other qualified healthcare professional before starting, changing, or stopping any kind of health treatment. Phone: 215-898-4713 {"smallUrl":"https:\/\/www.wikihow.com\/images\/thumb\/e\/ee\/Treat-Trimethylaminuria-Step-1.jpg\/v4-460px-Treat-Trimethylaminuria-Step-1.jpg","bigUrl":"\/images\/thumb\/e\/ee\/Treat-Trimethylaminuria-Step-1.jpg\/aid5176355-v4-728px-Treat-Trimethylaminuria-Step-1.jpg","smallWidth":460,"smallHeight":345,"bigWidth":728,"bigHeight":546,"licensing":"
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